Depending upon the site of origin, mesothelioma can be of three main types
Pleural mesothelioma (cancer of the lung lining) is by far the most common type making up about ninety percent of all cases. The peritoneum is the second most frequent site of origin of mesothelioma, after the pleura. Pericardial mesotheliomas are relatively rare.
All 3 types of mesotheliomas (pleural, peritoneal and pericardial) are very similar in behavior.
Another type is mesothelioma of the Tunica Vaginalis Testis which is very rare. Only up to 100 cases of this type have been documented to date. The tumors arising in the genital tract are far less aggressive.